Long‐lasting reduction of brain 5‐hydroxytryptamine concentration by 3‐chloroamphetamine and 4‐chloroamphetamine in iprindole‐treated rats

@article{Fuller1974LonglastingRO,
  title={Long‐lasting reduction of brain 5‐hydroxytryptamine concentration by 3‐chloroamphetamine and 4‐chloroamphetamine in iprindole‐treated rats},
  author={Ray W. Fuller and John C. Baker},
  journal={Journal of Pharmacy and Pharmacology},
  year={1974},
  volume={26}
}
  • R. Fuller, J. Baker
  • Published 1 November 1974
  • Biology, Chemistry
  • Journal of Pharmacy and Pharmacology
Previously we have shown that 3-chloroamphetamine has little effect on brain 5-hydroxytryptamine concentrations in rats because it is rapidly metabolized by ring hydroxylation, but if that route of metabolism is blocked, then 3-chloroamphetamine lowers brain 5-hydroxytryptamine concentrations as effectively as does 4-chloroamphetamine (Fuller, Schaffer & others, 1972). Those results were obtained at short times after the chloroamphetamines, and the duration of action of the drugs was not… 
7 Citations
CEREBRAL METABOLISM OF SOME SEROTONIN DEPLETORS *
  • E. Gal, A. Sherman
  • Chemistry, Biology
    Annals of the New York Academy of Sciences
  • 1978
TLDR
The scope of this paper, of necessity, is confined to the description of the nature of some of the cerebral metabolites of p-CA and FE and their implication as to the neurotoxicity of their parent drugs.
Cerebral metabolism of [3 H]-p-chloroamphetamine
Neurotoxicity in Dopamine and 5‐Hydroxytryptamine Terminal Fields: A Regional Analysis in Nigrostriatal and Mesolimbic Projections
TLDR
A differential sensitivity of the 5-HT and DA systems to the toxic effect of MA is speculative, but may be related to the differential formation of toxins due to the differing availability of oxygen and superoxides at serotonergic and dopaminergic synapses.
STRUCTURE‐ACTIVITY RELATIONSHIPS AMONG THE HALOGENATED AMPHETAMINES
  • R. Fuller
  • Biology, Chemistry
    Annals of the New York Academy of Sciences
  • 1978
p-Chloroamphetamine and various analogs influence brain serotonin neurons through multiple actions. Comparison of these compounds has permitted the distinction between short-term and long-term

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