Long‐Term Valproate and Lamotrigine Treatment May Be a Marker for Reduced Growth and Bone Mass in Children with Epilepsy

@article{Guo2001LongTermVA,
  title={Long‐Term Valproate and Lamotrigine Treatment May Be a Marker for Reduced Growth and Bone Mass in Children with Epilepsy},
  author={C. Y. Guo and Gabriel M Ronen and Stephanie A Atkinson},
  journal={Epilepsia},
  year={2001},
  volume={42}
}
Summary:  Purpose: To determine whether long‐term treatment with valproate (VPA) and/or lamotrigine (LTG) in children with epilepsy is associated with altered growth and/or bone metabolism. 
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Growth and bone metabolism were evaluated in 27 boys and 26 girls with epilepsy treated with valproate and/or lamotrigine for >2 years, in a study at McMaster University and Children’s Hospital, Hamilton, Ontario, Canada.
Effect of levetiracetam and oxcarbazepine on 4‐year fragility fracture risk among prepubertal and pubertal children with epilepsy
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Two commonly prescribed antiseizure medications, levetiracetam (LEV) and oxcarbazepine (OXC), were associated with an increased risk of fragility fracture in children with epilepsy when initiating therapy during a crucial period of bone development, namely, pre- and midpuberty.
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The effect of Phenytoin and valproate and levetiracetam on bone mass, biomechanical strength, and bone turnover in rats is compared.
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The influence of chronic monotherapy with antiepileptic drugs (AEDs) on vitamin D levels, bone metabolism, and body composition was determined.
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TLDR
This work investigated the effect of new antiepileptic drug, oxcarbazepine, on bone metabolism and found it to cause alteration in bone metabolism.
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A 55-year-old woman has been on carbamazepine for 30 years with excellent control of her partial-onset seizures. In the past when an attempt was made to switch her to lamotrigine or levetiracetam,…
Physical Growth and Endocrinal Disorders during Pubertal Maturation in Girls with Epilepsy
Summary:  Purpose: This study investigated the effect of epilepsy and/or antiepileptic drugs (AEDs) on the physical growth, pubertal development, and androgenic status of girls with epilepsy between…
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