Long‐Term Evaluation of Bone Formation by Osteogenic Protein 1 in the Baboon and Relative Efficacy of Bone‐Derived Bone Morphogenetic Proteins Delivered by Irradiated Xenogeneic Collagenous Matrices

@article{Ripamonti2000LongTermEO,
  title={Long‐Term Evaluation of Bone Formation by Osteogenic Protein 1 in the Baboon and Relative Efficacy of Bone‐Derived Bone Morphogenetic Proteins Delivered by Irradiated Xenogeneic Collagenous Matrices},
  author={Ugo Ripamonti and B van den Heever and Jean Crooks and Marjorie M. Tucker and T. Kuber Sampath and David C. Rueger and A. Hari Reddi},
  journal={Journal of Bone and Mineral Research},
  year={2000},
  volume={15}
}
To investigate the long‐term efficacy of irradiated recombinant human osteogenic protein 1 (hOP‐1) in bone regeneration and morphogenesis, hOP‐1 was combined with a bovine collagenous matrix carrier (0, 0.1, 0.5, and 2.5 mg hOP‐1/g of matrix), sterilized with 2.5 Mrads of γ‐irradiation, and implanted in 80 calvarial defects in 20 adult baboons (Papio ursinus). The relative efficacy of partially purified bone‐derived baboon bone morphogenetic proteins (BMPs), known to contain several osteogenic… 
Bone induction by recombinant human osteogenic protein‐1 (hOP‐1, BMP‐7) in the primate Papio ursinus with expression of mRNA of gene products of the TGF‐β superfamily
  • U. Ripamonti
  • Biology
    Journal of cellular and molecular medicine
  • 2005
TLDR
The induction of bone by hOP‐1 in Papio ursinus develops as a mosaic structure with distinct spatial and temporal patterns of gene expression of members of the TGF‐β superfamily that singly, synergistically and synchronously initiate and maintain tissue induction and morphogenesis.
Periodontal tissue regeneration by combined applications of recombinant human osteogenic protein-1 and bone morphogenetic protein-2. A pilot study in Chacma baboons (Papio ursinus).
TLDR
Tissue morphogenesis induced by hOP-1 and hBMP-2 is qualitatively different when the morphogens are applied singly, with hop-1 inducing substantial cementogenesis, and the demonstration of therapeutic mosaicism in periodontal regeneration will require extensive testing of ratios and doses of recombinant morphogen combinations for optimal tissue engineering in clinical contexts.
Synergistic induction of periodontal tissue regeneration by binary application of human osteogenic protein-1 and human transforming growth factor-β3 in Class II furcation defects of Papio ursinus.
TLDR
Binary applications of hOP-1 and hTGF-β(3) in Matrigel(®) matrix in Class II furcation defects of P. ursinus induced substantial periodontal tissue regeneration, which was tempered by the anatomy of the furcation defect model, which does not allow for the rapid growth and expansion of the synergistic induction of bone formation.
Effect of recombinant human bone morphogenetic protein-2, -4, and -7 on bone formation in rat calvarial defects.
TLDR
Evaluated and compared the osteogenic potential of rhBMP-2, -4, and -7 delivered with absorbable collagen sponge (ACS) upon early (2 weeks) and complete (8 weeks) wound healing phases in a critical sized rat calvarial defect model, finding no specific differences in bone regenerative potential.
No effect of bone morphogenetic protein-7 (OP-1) on the incorporation of impacted bone grafts in a realistic acetabular model.
TLDR
The main question in this study was if BMP-7 (OP-1) mixed with MCB could accelerate the incorporation of MCB and prevents the formation of a soft tissue interface after remodeling of the MCB, and if this support the use of OP-1 in impaction bone grafting in patients.
Human Segmental Mandibular Defects Treated With Naturally Derived Bone Morphogenetic Proteins
TLDR
The osteogenic device (OD) was formulated as a combination of human demineralized bone matrix as delivery system reconstituted with naturally derived BMPs and, when successful, OD-treated defects had highly active osteogenesis compared with ABGs.
Bone Induction by BMPs/OPs and Related Family Members in Primates: The Critical Role of Delivery Systems
TLDR
This work focuses on the geometric induction of bone formation by sintered porous hydroxyapatite (SPHA) discs with concavities on their planar surfaces, which elicit bone formation without exogenously applied BMPs/OPs.
Effect of recombinant human bone morphogenetic protein-4 with carriers in rat calvarial defects.
TLDR
Surgical implantation of rhB MP-4/ACS may be used to support bone regeneration in the rat calvarial critical-sized defect, and rhBMP- 4/beta-TCP may be able to regenerate bone in theRat calvaria critical- sized defect without complication.
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