Long‐Term Diuretic Therapy with Metolazone of Renal Failure and the Nephrotic Syndrome

@article{Patn1977LongTermDT,
  title={Long‐Term Diuretic Therapy with Metolazone of Renal Failure and the Nephrotic Syndrome},
  author={Ram{\'o}n Rubio Pat{\'o}n and Robert E. Kane},
  journal={The Journal of Clinical Pharmacology},
  year={1977},
  volume={17}
}
The effects of the new diuretic metolazone were studied in ten patients with chronic renal insufficiency and ten with nephrotic syndrome. Patients were maintained on metolazone for up to 44 months. Beneficial effects of treatment included loss of edema and improved control of blood pressure. The natriuretic effect of metolazone facilitated the use of sodium bicarbonate to treat acidosis in several patients. Concurrent administration of metolazone and furosemide produced a dramatic diuresis in… Expand
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