Loneliness in late-life depression: structural and functional connectivity during affective processing.

@article{Wong2016LonelinessIL,
  title={Loneliness in late-life depression: structural and functional connectivity during affective processing.},
  author={N. M. Wong and H. Liu and C. Lin and C-M. Huang and Y-Y Wai and S. Lee and T. M. Lee},
  journal={Psychological medicine},
  year={2016},
  volume={46 12},
  pages={
          2485-99
        }
}
BACKGROUND Late-life depression (LLD) in the elderly was reported to present with emotion dysregulation accompanied by high perceived loneliness. Previous research has suggested that LLD is a disorder of connectivity and is associated with aberrant network properties. On the other hand, perceived loneliness is found to adversely affect the brain, but little is known about its neurobiological basis in LLD. The current study investigated the relationships between the structural connectivity… Expand
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  • 11
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  • 3
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  • 6
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  • 45
  • PDF
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  • 2
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  • 2
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References

SHOWING 1-10 OF 77 REFERENCES
Brain Network Dysfunction in Late-Life Depression
  • 68
Brain Structure Links Loneliness to Social Perception
  • 96
  • PDF
Graph theory analysis of cortical-subcortical networks in late-life depression.
  • 68
  • Highly Influential
Resting-state functional connectivity abnormalities in first-onset unmedicated depression
  • 37
  • PDF
Association of brain network efficiency with aging, depression, and cognition.
  • Olusola Ajilore, M. Lamar, A. Kumar
  • Psychology, Medicine
  • The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
  • 2014
  • 29
  • Highly Influential
Resting-State Functional Connectivity in Late-Life Depression: Higher Global Connectivity and More Long Distance Connections
  • 63
  • PDF
Altered functioning of the executive control circuit in late-life depression: episodic and persistent phenomena.
  • H. Aizenstein, M. Butters, +6 authors C. Carter
  • Psychology, Medicine
  • The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
  • 2009
  • 130
Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology in the Chicago Health, Aging, and Social Relations Study.
  • 799
  • Highly Influential
  • PDF
Loneliness as a specific risk factor for depressive symptoms: cross-sectional and longitudinal analyses.
  • 1,239
  • Highly Influential
  • PDF
Aberrant topology of striatum's connectivity is associated with the number of episodes in depression.
  • 121
  • PDF
...
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2
3
4
5
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