London–East Anglia randomised controlled trial of cognitive–behavioural therapy for psychosis

@article{Kuipers1997LondonEastAR,
  title={London–East Anglia randomised controlled trial of cognitive–behavioural therapy for psychosis},
  author={Elizabeth Kuipers and Philippa A. Garety and David Fowler and Graham Dunn and Paul E. Bebbington and Daniel Freeman and Clare Hadley},
  journal={British Journal of Psychiatry},
  year={1997},
  volume={171},
  pages={319 - 327}
}
Background A series of small, mainly uncontrolled, studies have suggested that techniques adapted from cognitive–behavioural therapy (CBT) for depression can improve outcome in psychosis, but no large randomised controlled trial of intensive treatment for medication-resistant symptoms of psychosis has previously been published. Method Sixty participants who each had at least one positive and distressing symptom of psychosis that was medication-resistant were randomly allocated between a CBT and… 
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TLDR
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It is argued that positive outcome in CBT is due in part to specific effects on delusional thinking, which is strongly predicted in patients with persistent delusions by a cognitive measure, while this was not the case in controls.
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The applicability, acceptability and effectiveness of CBTp when offered routinely in a public mental health service, and working alliance and client satisfaction measures indicated excellent acceptability, are evaluated.
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There was significant differences in the reductions in thought disorder and negative symptoms with an advantage of cognitive-behaviour therapy compared to routine care and there was no evidence that a reduction in positive symptoms was associated with an increase in depressing symptoms.
[Cognitive-behavioural therapy in early psychosis: an open study in a clinical setting].
TLDR
Meta-analysis results confirm that cognitive-behavioural therapy in psychosis (CBTp) is efficient for persistent symptoms, and CBTp seems to be appropriate in clinical settings, including with adolescents, as well as with adolescents.
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The study provides evidence for the feasibility and effectiveness for targeting CBT on the appearance of early signs of relapse in schizophrenia and shows significantly greater improvement in positive symptoms, negative symptoms, global psychopathology, performance of independent functions and prosocial activities.
Effectiveness of a brief cognitive-behavioural therapy intervention in the treatment of schizophrenia.
TLDR
Community psychiatric nurses can safely and effectively deliver a brief cognitive-behavioural therapy intervention to patients with schizophrenia and their carers.
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London–East Anglia randomised controlled trial of cognitive–behavioural therapy for psychosis
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