Lonchocarpus sericeus lectin decreases leukocyte migration and mechanical hypernociception by inhibiting cytokine and chemokines production.

@article{Napimoga2007LonchocarpusSL,
  title={Lonchocarpus sericeus lectin decreases leukocyte migration and mechanical hypernociception by inhibiting cytokine and chemokines production.},
  author={Marcelo Henrique Napimoga and Benildo Sousa Cavada and Nylane Maria Nunes de Alencar and M{\'a}rio Rog{\'e}rio Lima Mota and Fl{\'a}vio S Bittencourt and Jose C Alves-Filho and Renata Grespan and Reginaldo Bruno Gonçalves and Juliana Trindade Clemente-Napimoga and Andressa de Freitas and Carlos Am{\'i}lcar Parada and S{\'e}rgio Henrique Ferreira and Fernando Queiroz Cunha},
  journal={International immunopharmacology},
  year={2007},
  volume={7 6},
  pages={824-35}
}
In this study, we tested the potential use of a lectin from Lonchocarpus sericeus seeds (LSL), to control neutrophil migration and inflammatory hypernociception (decrease of nociceptive threshold). Pretreatment of the animals intravenously (15 min before) with LSL inhibited neutrophil migration to the peritoneal cavity in a dose-dependent fashion confirmed by an inhibition of rolling and adhesion of leukocytes by intravital microscopy. We also tested the ability of the pretreatment with LSL to… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
injection of OVA in immunized mice and of carrageenan in naïve mice , but not that induced by prostaglandin E(2 ) ( PGE(2 ) ) or formalin .
All Topics