Lon protease quality control of presecretory proteins in Escherichia coli and its dependence on the SecB and DnaJ (Hsp40) chaperones.

@article{Sakr2010LonPQ,
  title={Lon protease quality control of presecretory proteins in Escherichia coli and its dependence on the SecB and DnaJ (Hsp40) chaperones.},
  author={Samer Sakr and A Cirinesi and Ronald S. Ullers and Françoise Schwager and Costa P. Georgopoulos and Pierre Genevaux},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 30},
  pages={23506-14}
}
Various environmental insults result in irreversible damage to proteins and protein complexes. To cope, cells have evolved dedicated protein quality control mechanisms involving molecular chaperones and proteases. Here, we provide both genetic and biochemical evidence that the Lon protease and the SecB and DnaJ/Hsp40 chaperones are involved in the quality control of presecretory proteins in Escherichia coli. We showed that mutations in the lon gene alleviate the cold-sensitive phenotype of a… CONTINUE READING
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