Lon-dependent regulation of the DNA binding protein HU in Escherichia coli.

  title={Lon-dependent regulation of the DNA binding protein HU in Escherichia coli.},
  author={Eliette Bonnefoy and Agostinho Almeida and Josette Rouviere-Yaniv},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={86 20},
HU, the major DNA binding protein of Escherichia coli, exists in solution as a heterodimer composed of two highly homologous subunits: HU1, encoded by hupB; HU2, encoded by hupA. The purification of the HU protein from hupA- or hupB- bacteria showed that the hupB mutant strains synthesize normal amounts of the HU2 subunit (which corresponds to 60% of the total HU present in wild-type cells). On the contrary, the amount of HU1 present in hupA mutant strains corresponds to only 6% of the total HU… CONTINUE READING

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