Lomitapide at supratherapeutic plasma levels does not prolong the Qtc interval--results from a TQT study with moxifloxacin and ketoconazole.


BACKGROUND The aim of this study was to assess the effect of high plasma levels of lomitapide and its main metabolite on ECG parameters. METHODS In this randomized five-way cross-over thorough QT study, 56 healthy subjects were enrolled. Study treatments were administered orally for 3 days in five separate periods in which subjects were dosed with (1) a… (More)
DOI: 10.1111/anec.12103


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