Lomitapide: a novel drug for homozygous familial hypercholesterolemia

@article{Panno2014LomitapideAN,
  title={Lomitapide: a novel drug for homozygous familial hypercholesterolemia},
  author={Maria D. Panno and Angelo B. Cefal{\`u} and Maurizio Rocco Averna},
  journal={Clinical Lipidology},
  year={2014},
  volume={9},
  pages={19 - 32}
}
Abstract Lomitapide (Juxtapid® and Lojuxta®; Aegerion Pharmaceuticals, Inc., MA, USA), an orally administered inhibitor of the microsomal triglyceride transfer protein, inhibits the synthesis and secretion of ApoB‑containing lipoproteins and, thus, reduces plasma levels of low‑density lipoprotein cholesterol (LDL‑C). Lomitapide has been approved for the therapy of homozygous familial hypercholesterolemia patients. After a proof‑of‑concept Phase II trial, lomitapide has been tested in a… 
Therapeutic options for homozygous familial hypercholesterolemia: the role of Lomitapide.
TLDR
Lomitapide represents an innovative and efficacious drug for the treatment of HoFH and long-term safety data, treatment of pediatric and pregnant HoFH patients and management of severe hypertriglyceridemia still requires further investigations.
Lomitapide treatment in a female with homozygous familial hypercholesterolaemia: a case report
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It is suggested that lomitapide can be a drug of choice in patients with homozygous FH, as it contributed to improved LDL-C levels, a reduction in LDL apheresis sessions and enhanced quality of life.
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