Logic Functions of the Genomic Cis-regulatory Code

  title={Logic Functions of the Genomic Cis-regulatory Code},
  author={Eric H. Davidson and Sorin Istrail},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 14},
cis-Regulatory modules that control developmental gene expression process the regulatory inputs provided by the transcription factors for which they contain specific target sites. A prominent class of cis-regulatory processing functions can be modeled as logic operations. Many of these are combinatorial because they are mediated by multiple sites, although others are unitary. In this work, we illustrate the repertoire of cis-regulatory logic operations, as an approach toward a functional… CONTINUE READING