LogP, a yesterday's value?


INTRODUCTION There is an increasing demand for high throughput methods at early stages of preclinical radioligand development, in order to predict pharmacokinetic properties (e.g., biodistribution) and blood brain barrier (BBB) penetration. One of the most important physicochemical properties is the lipophilicity, measured by means of shake-flask (logP) or… (More)
DOI: 10.1016/j.nucmedbio.2017.03.003


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