Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC

@inproceedings{Kwon2017LocusspecificHD,
  title={Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC},
  author={Deborah Y. Kwon and Ying-tao Zhao and Janine M. Lamonica and Zhaolan Zhou},
  booktitle={Nature communications},
  year={2017}
}
Efforts to manipulate locus-specific histone acetylation to assess their causal role in gene expression and cellular and behavioural phenotypes have been impeded by a lack of experimental tools. The Cas9 nuclease has been adapted to target epigenomic modifications, but a detailed description of the parameters of such synthetic epigenome remodellers is still lacking. Here we describe a Cas9-based histone deacetylase (HDAC) and the design principles required to achieve locus-specific histone… CONTINUE READING
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