Locus-specific heritability estimation via the bootstrap in linkage scans for quantitative trait loci.

BACKGROUND/AIMS In genome-wide linkage analysis of quantitative trait loci (QTL), locus-specific heritability estimates are biased when the original data are used to both localize linkage and estimate effects, due to maximization of the LOD score over the genome. Positive bias is increased by adoption of stringent significance levels to control genome-wide… CONTINUE READING