Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors

  title={Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors},
  author={Elizabeth A. Heller and Hannah M. Cates and Catherine Jensen Pe{\~n}a and HaoSheng Sun and Ning-Yi Shao and Jian Feng and Sam A. Golden and James P. Herman and Jessica J. Walsh and Michelle S Mazei-Robison and Deveroux Ferguson and Scott W. Knight and Mark A. Gerber and Christian J Nievera and Ming-Hu Han and Scott J. Russo and Carol Tamminga and Rachael L. Neve and Li Shen and H. Steve Zhang and Feng Zhang and Eric J. Nestler},
  journal={Nature Neuroscience},
Chronic exposure to drugs of abuse or stress regulates transcription factors, chromatin-modifying enzymes and histone post-translational modifications in discrete brain regions. Given the promiscuity of the enzymes involved, it has not yet been possible to obtain direct causal evidence to implicate the regulation of transcription and consequent behavioral plasticity by chromatin remodeling that occurs at a single gene. We investigated the mechanism linking chromatin dynamics to neurobiological… 
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