Locus of Adhesion and Autoaggregation (LAA), a pathogenicity island present in emerging Shiga Toxin–producing Escherichia coli strains

@article{Montero2017LocusOA,
  title={Locus of Adhesion and Autoaggregation (LAA), a pathogenicity island present in emerging Shiga Toxin–producing Escherichia coli strains},
  author={David A. Montero and Juliana Velasco and Felipe Del Canto and José Luis Puente and Nora L Padola and David A. Rasko and Mauricio J. Farf{\'a}n and Juan Carlos Salazar and Roberto M. Vidal},
  journal={Scientific Reports},
  year={2017},
  volume={7}
}
Shiga Toxin-producing Escherichia coli (STEC) are a group of foodborne pathogens associated with diarrhea, dysentery, hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS). Shiga toxins are the major virulence factor of these pathogens, however adhesion and colonization to the human intestine is required for STEC pathogenesis. A subset of STEC strains carry the Locus of Enterocyte Effacement (LEE) pathogenicity island (PAI), which encodes genes that mediate the colonization of the human… Expand
First report of the distribution of Locus of Adhesion and Autoaggregation (LAA) pathogenicity island in LEE-negative Shiga toxin-producing Escherichia coli isolates from Argentina.
TLDR
The results of this study contribute to a better understanding regarding the pathogenicity of this emergent subset of STEC strains harboring LAA as a predictor of virulence of LEE-negative STec strains. Expand
Distribution of Locus of Adhesion and Autoaggregation and hes Gene in STEC Strains from Countries of Latin America
TLDR
Analysis of the distribution of LAA and its possible predictor, the gene hes, in LEE-negative STEC strains isolated from Chile and Paraguay from different sources found the presence of the different LAA modules and hes were detected by PCR. Expand
Cumulative acquisition of pathogenicity islands has shaped virulence potential and contributed to the emergence of LEE-negative Shiga toxin-producing Escherichia coli strains
TLDR
Comprehensive and rigorous comparative genomic and phylogenetic analyses suggest that the accumulative acquisition of PAIs has played an important, but currently unappreciated role, in the evolution of virulence in these strains. Expand
Biofilm formation by LEE-negative Shiga Toxin-Producing Escherichia coli strains.
TLDR
Compared different serogroup of LEE-negative STEC strains in their ability to form biofilms and to evaluate the participation of some genes encoding in LAA, it was found a high variability between them. Expand
Novel type of pilus associated with a Shiga-toxigenic E. coli hybrid pathovar conveys aggregative adherence and bacterial virulence
TLDR
Describing widely distributed and novel fimbriae that are essential for aggregative adherence and cytotoxicity in a LEE-negative Shiga-toxigenic hybrid is characterized. Expand
Pathogenicity Factors of Genomic Islands in Intestinal and Extraintestinal Escherichia coli
TLDR
A review of a subgroup of GIs from E. coli termed pathogenicity islands (PAIs), a concept defined in the late 1980s by Jörg Hacker and colleagues in Werner Goebel’s group at the University of WürZburg, Würzburg, Germany, which is summarized in this review. Expand
Deciphering Additional Roles for the EF-Tu, l-Asparaginase II and OmpT Proteins of Shiga Toxin-Producing Escherichia coli
TLDR
The results show that the EF-Tu and l-asparaginase II are secreted by O157:H7 and may also localize on the surface of this bacterium, and OmpT, a well characterized protease, shows its participation in the adhesion of O157?:H7 to human epithelial cells. Expand
Pathogenicity assessment of Shiga toxin‐producing Escherichia coli (STEC) and the public health risk posed by contamination of food with STEC
TLDR
All STEC strains are pathogenic in humans, capable of causing at least diarrhoea and that all STEC subtypes may be associated with severe illness. Expand
Virulence Profiling and Molecular Typing of Shiga Toxin-Producing E. coli (STEC) from Human Sources in Brazil
TLDR
A diversity of other serotypes, some carrying virulence genes and belonging to STs incriminated as causing severe disease, were found in this study, suggesting new STs. Expand
Genomic Investigation of Virulence Potential in Shiga Toxin Escherichia coli (STEC) Strains From a Semi-Hard Raw Milk Cheese
TLDR
Evaluating the main genomic features of STEC strains isolated from a semi-hard raw milk cheese adds new knowledge on STEC monitoring in raw milk dairy products, underlining the fundamental role of whole genome sequencing (WGS) for typing these unknown isolates. Expand
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