Locus coeruleus neurons: cessation of activity during cataplexy.

  title={Locus coeruleus neurons: cessation of activity during cataplexy.},
  author={Min Fan Wu and Seema Gulyani and Edward Hon-Hei Yau and Emmanuel Mignot and Bick Phan and Jerome M Siegel},
  volume={91 4},
Cataplexy, a symptom of narcolepsy, is a loss of muscle tone usually triggered by sudden, emotionally significant stimuli. We now report that locus coeruleus neurons cease discharge throughout cataplexy periods in canine narcoleptics. Locus coeruleus discharge rates during cataplexy were as low as or lower than those seen during rapid-eye-movement sleep. Prazosin, an alpha1 antagonist, and physostigmine, a cholinesterase inhibitor, both of which precipitate cataplexy, decreased locus coeruleus… CONTINUE READING