Locus coeruleus mediates cold stress-induced polycystic ovary in rats.

@article{Bernuci2008LocusCM,
  title={Locus coeruleus mediates cold stress-induced polycystic ovary in rats.},
  author={Marcelo Picinin Bernuci and Raphael Escorsim Szawka and Cleyde Vanessa Vega Helena and Cristiane Mota Leite and Hern{\'a}n E. Lara and Janete Aparecida Anselmo-Franci},
  journal={Endocrinology},
  year={2008},
  volume={149 6},
  pages={2907-16}
}
Previous reports about the rat ovary have shown that cold stress promotes ovarian morphological alterations related to a polycystic ovary (PCO) condition through activation of the ovarian sympathetic nerves. Because the noradrenergic nucleus locus coeruleus (LC) is activated by cold stress and synaptically connected to the preganglionic cell bodies of the ovarian sympathetic pathway, this study aimed to evaluate the LC's role in cold stress-induced PCO in rats. Ovarian morphology and endocrine… CONTINUE READING