Locus coeruleus is a central chemoreceptive site in toads.
@article{NoronhadeSouza2006LocusCI,
title={Locus coeruleus is a central chemoreceptive site in toads.},
author={Carolina R. Noronha-de-Souza and K{\^e}nia Cardoso B{\'i}cego and Gustavo Michel and Mogens Lesner Glass and Luiz G. S. Branco and Luciane Helena Gargaglioni},
journal={American journal of physiology. Regulatory, integrative and comparative physiology},
year={2006},
volume={291 4},
pages={
R997-1006
}
}The locus coeruleus (LC) has been suggested as a CO2 chemoreceptor site in mammals. This nucleus is a mesencephalic structure of the amphibian brain and is probably homologous to the LC in mammals. There are no data available for the role of LC in the central chemoreception of amphibians. Thus the present study was designed to investigate whether LC of toads (Bufo schneideri) is a CO2/H+ chemoreceptor site. Fos immunoreactivity was used to verify whether the nucleus is activated by hypercarbia…
45 Citations
The locus coeruleus and central chemosensitivity
- BiologyRespiratory Physiology & Neurobiology
- 2010
Neurochemical and electrical modulation of the locus coeruleus: contribution to CO2drive to breathe
- BiologyFront. Physiol.
- 2014
The locus coeruleus (LC) is a dorsal pontine region, situated bilaterally on the floor of the fourth ventricle. It is considered to be the major source of noradrenergic innervation in the brain.…
Role of pontine neurons in central O2 chemoreflex during development in bullfrogs (Lithobates catesbeiana)
- BiologyNeuroscience
- 2008
Locus Coeruleus in Non-Mammalian Vertebrates
- BiologyBrain sciences
- 2022
The locus coeruleus (LC) is a vertebrate-specific nucleus and the primary source of norepinephrine (NE) in the brain. This nucleus has conserved properties across species: highly homogeneous cell…
Role of sex hormones in hypercapnia-induced activation of the locus coeruleus in female and male rats
- BiologyNeuroscience
- 2016
Temperature influences neuronal activity and CO2/pH sensitivity of locus coeruleus neurons in the bullfrog, Lithobates catesbeianus.
- BiologyAmerican journal of physiology. Regulatory, integrative and comparative physiology
- 2013
Modulation of cellular chemosensitivity within the LC during temperature changes may influence temperature-dependent respiratory drive during acid-base disturbances in amphibians, and cold-activated/warm-inhibited LC neurons introduce paradoxical temperature sensitivity in respiratory control neurons of amphibians.
Midbrain Structures and Control of Ventilation in Amphibians
- Biology
- 2009
This chapter reviews the available data on the role of the nucleus isthmi and LC in the control of ventilation in amphibians and reports that this nucleus is a CO2-sensitive receptor site in amphibian, which mediates the ventilatory response to hypercapnia.
Orexin in the toad Rhinella schneideri: The location of orexinergic neurons and the role of orexin in ventilatory responses to hypercarbia and hypoxia
- BiologyRespiratory Physiology & Neurobiology
- 2016
Effect of temperature on chemosensitive locus coeruleus neurons of savannah monitor lizards, Varanus exanthematicus
- BiologyJournal of Experimental Biology
- 2016
CO2 chemosensitivity is temperature dependent in savannah monitor lizards, where the proportion of locus coeruleus neurons excited or inhibited by CO2 changes with changes in temperature.
Respiratory signaling of locus coeruleus neurons during hypercapnic acidosis in the bullfrog, Lithobates catesbeianus
- BiologyRespiratory Physiology & Neurobiology
- 2013
References
SHOWING 1-10 OF 73 REFERENCES
Retrotrapezoid nucleus: a litmus test for the identification of central chemoreceptors.
- BiologyExperimental physiology
- 2005
It is suggested that many fewer medullary neurones are intrinsically responsive to CO2 in vivo than might have been anticipated from prior experimentation in vitro.
Thermoeffector neuronal pathways in fever: a study in rats showing a new role of the locus coeruleus
- BiologyThe Journal of physiology
- 2004
It is concluded that LC neurones are part of a neuronal network that is specifically activated by PGE2 to increase thermogenesis and produce fever.
Central chemosensitivity, sleep, and wakefulness
- BiologyRespiration physiology
- 2001
This review evaluates data obtained from unanesthetized rats at three central chemoreceptor sites, the retrotrapezoid nucleus (RTN), the medullary raphé, and the nucleus tractus solitarius (NTS) and extends ideas concerning two hypotheses, which were recently formulated.
Re: Retrotrapezoid nucleus: a litmus test for the identification of central chemoreceptors
- Biology
- 2005
This work has shown that TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor in freely moving cats and that ATP is a key mediator of central and peripheral chemosensory transduction.
Location of central respiratory chemoreceptors in the developing tadpole.
- BiologyAmerican journal of physiology. Regulatory, integrative and comparative physiology
- 2001
It is concluded that, as in lung rhythmogenic function, respiratory chemosensitivity emerges rostrally in the amphibian brain stem during development.
Homing in on the specific phenotype(s) of central respiratory chemoreceptors.
- BiologyExperimental physiology
- 2005
There is evidence supporting a role in respiratory chemoreception for both types of neurone, as well as the other candidates, but there is also information that is missing.
Do amphibians have a true locus coeruleus?
- BiologyNeuroreport
- 1996
Applications of Texas Red-conjugated dextran amines to the basal telencephalon or to the spinal cord in combination with tyrosine hydroxylase immunohistochemistry revealed that the noradrenergic cell bodies in the isthmic region of anuran and urodele amphibians project to the telencephon as well as to the spine.
Widespread sites of brain stem ventilatory chemoreceptors.
- BiologyJournal of applied physiology
- 1993
It is concluded that central chemoreceptors are distributed at many locations within the brain stem, all within 1.5 mm of the surface, and that stimulation of a small fraction of all central che moreceptors can result in a large ventilatory response.
Chemical lesions of the nucleus isthmi increase the hypoxic and hypercarbic drive to breathing of toads
- BiologyRespiratory Physiology & Neurobiology
- 2002
Role of intracellular and extracellular pH in the chemosensitive response of rat locus coeruleus neurones
- BiologyThe Journal of physiology
- 2002
An increased firing rate of LC neurones in response to acid challenges was best correlated with the magnitude and the rate of fall in p Hi, indicating that a decrease in pHi is a major part of the intracellular signalling pathway that transduces an acid challenge into an increase firing rate in LC neurone.






