Locus coeruleus integrity in old age is selectively related to memories linked with salient negative events

Abstract

The locus coeruleus (LC) is the principal origin of noradrenaline in the brain. LC integrity varies considerably across healthy older individuals, and is suggested to contribute to altered cognitive functions in aging. Here we test this hypothesis using an incidental memory task that is known to be susceptible to noradrenergic modulation. We used MRI… (More)
DOI: 10.1073/pnas.1712268115

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