Locus coeruleus at asymptomatic early and middle Braak stages of neurofibrillary tangle pathology.

@article{Benito2017LocusCA,
  title={Locus coeruleus at asymptomatic early and middle Braak stages of neurofibrillary tangle pathology.},
  author={Pol Andres Benito and V{\'i}ctor Fern{\'a}ndez-Due{\~n}as and Margarita Carmona and Laura A. Escobar and Benjam{\'i}n Torrej{\'o}n-Escribano and Ester As{\'o} and Francisco Ciruela and Isidro Ferrer},
  journal={Neuropathology and applied neurobiology},
  year={2017},
  volume={43 5},
  pages={373-392}
}
AIMS The present study analyses molecular characteristics of the locus coeruleus (LC) and projections to the amygdala and hippocampus at asymptomatic early and middle Braak stages of neurofibrillary tangle (NFT) pathology. METHODS Immunohistochemistry, whole-transcriptome arrays and RT-qPCR in LC and western blotting in hippocampus and amygdala in a cohort of asymptomatic individuals at stages I-IV of NFT pathology were used. RESULTS NFTs in the LC increased in parallel with colocalized… CONTINUE READING
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