Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment.

@article{Gompf2010LocusCA,
  title={Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment.},
  author={Heinrich S. Gompf and Christine Mathai and Patrick M Fuller and David A. Wood and Nigel P. Pedersen and Clifford B. Saper and Jun Lu},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 43},
  pages={14543-51}
}
Locus ceruleus (LC) neuronal activity is correlated with the waking state, yet LC lesions produce only minor alterations in daily wakefulness. Here, we report that sustained elevations in neurobehavioral and EEG arousal in response to exposure to an environment with novel stimuli, including social interaction, are prevented by selective chemical lesions of the LC in rats. Similar results are seen when the anterior cingulate cortex (ACC), which receives especially dense LC innervation, is… CONTINUE READING

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Prefrontal cortex. In: The cerebral cortex of the rat

  • B Kolb
  • (Kolb B, Tees RC,
  • 1990
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