Locus Coeruleus in time with the making of memories

@article{Sara2015LocusCI,
  title={Locus Coeruleus in time with the making of memories},
  author={Susan Sara},
  journal={Current Opinion in Neurobiology},
  year={2015},
  volume={35},
  pages={87-94}
}
  • S. Sara
  • Published 1 December 2015
  • Biology, Psychology
  • Current Opinion in Neurobiology

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TLDR
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References

SHOWING 1-10 OF 59 REFERENCES
Reactivation, Retrieval, Replay and Reconsolidation in and Out of Sleep: Connecting the Dots
  • S. Sara
  • Psychology, Biology
    Front. Behav. Neurosci.
  • 2010
TLDR
It is suggested that the noradrenergic system and perhaps other neuromodulatory systems, may be a key to linking off-line memory reactivation, retrieval, and memory reconsolidation processes at both synaptic and systems levels, in and out of sleep.
The locus coeruleus and noradrenergic modulation of cognition
  • S. Sara
  • Psychology, Biology
    Nature Reviews Neuroscience
  • 2009
TLDR
Elucidating the factors that control the activity of these neurons and the effect of noradrenaline in target regions is key to understanding how the brain allocates attention and apprehends the environment to select, store and retrieve information for generating adaptive behaviour.
Selective tuning of hippocampal oscillations by phasic locus coeruleus activation in awake male rats
TLDR
Dentate gyrus EEG was examined during glutamatergic activation of the LC in awake male rats in relation to plasticity effects on simultaneously recorded perforant path‐evoked field potentials to suggest oscillatory tuning within the theta and gamma range may facilitate shifts in cognitive set.
Noradrenergic action in prefrontal cortex in the late stage of memory consolidation.
TLDR
The results of these experiments confirm earlier pharmacological and immunohistochemical studies suggesting a delayed role of noradrenaline in a late phase of long-term memory consolidation and the engagement of the PL during these consolidation processes.
Locus coeruleus neuromodulation of memories encoded during negative or unexpected action outcomes
Plasticity of sensory responses of locus coeruleus neurons in the behaving rat: implications for cognition.
The prefrontal cortex and its relation to behavior.
  • J. Fuster
  • Biology, Psychology
    Progress in brain research
  • 1991
Memorable Trends
...
...