Locus Coeruleus Norepinephrine in Learned Behavior: Anatomical Modularity and Spatiotemporal Integration in Targets

@article{BretonProvencher2021LocusCN,
  title={Locus Coeruleus Norepinephrine in Learned Behavior: Anatomical Modularity and Spatiotemporal Integration in Targets},
  author={Vincent Breton-Provencher and Gabrielle T. Drummond and Mriganka Sur},
  journal={Frontiers in Neural Circuits},
  year={2021},
  volume={15}
}
The locus coeruleus (LC), a small brainstem nucleus, is the primary source of the neuromodulator norepinephrine (NE) in the brain. The LC receives input from widespread brain regions, and projects throughout the forebrain, brainstem, cerebellum, and spinal cord. LC neurons release NE to control arousal, but also in the context of a variety of sensory-motor and behavioral functions. Despite its brain-wide effects, much about the role of LC-NE in behavior and the circuits controlling LC activity… 

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References

SHOWING 1-10 OF 154 REFERENCES
Redefining Noradrenergic Neuromodulation of Behavior: Impacts of a Modular Locus Coeruleus Architecture
TLDR
The concept of theLC as a singular nucleus and the role of the LC in diverse theories of brain function must be reconsidered based on the evidence supporting a modular LC based on multiple levels of observation.
Locus coeruleus: From global projection system to adaptive regulation of behavior
Modular organization of the brainstem noradrenaline system coordinates opposing learning states
TLDR
A modular LC organization is reported in rats, endowed with distinct neural projection patterns and coding properties for flexible specification of opposing behavioral learning states, enabling adaptive tuning of emotional responding and behavioral flexibility.
Locus coeruleus activation accelerates perceptual learning
An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance.
Historically, the locus coeruleus-norepinephrine (LC-NE) system has been implicated in arousal, but recent findings suggest that this system plays a more complex and specific role in the control of
Locus coeruleus: a new look at the blue spot
TLDR
Major compelling questions about the functional role of the locus coeruleus nucleus that had been difficult to answer, given its remote location and diminutive size have now become accessible via new neuroscience tools.
Active control of arousal by a locus coeruleus GABAergic circuit
TLDR
A local population of GABAergic neurons (LC-GABA) is revealed capable of modulating LC-NA activity and arousal, and how this circuit regulates arousal gain and tone is shown.
Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior
TLDR
It is demonstrated that photostimulation of LC-NE fibers in the BLA evokes norepinephrine release in the basolateral amygdala (BLA), alters BLA neuronal activity, conditions aversion, and increases anxiety-like behavior.
Identification of a Group of GABAergic Neurons in the Dorsomedial Area of the Locus Coeruleus
TLDR
An isolated group of GABAergic neurons is demonstrated in the LC area, whose location, somatic morphology and intrinsic membrane properties are clearly distinguishable from adjacent LC neurons.
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