Locoregional failure and the risk of distant metastasis after modern radiotherapy for head and neck cancer

@article{Dragovic2013LocoregionalFA,
  title={Locoregional failure and the risk of distant metastasis after modern radiotherapy for head and neck cancer},
  author={Aleksandar F. Dragovic and Jimmy J. Caudell and Sharon A. Spencer and William R. Carroll and Lisle Nabell and James A Bonner},
  journal={Head \& Neck},
  year={2013},
  volume={35}
}
Evolving epidemiology and improvements in locoregional therapy necessitate reassessment of the relationship between locoregional failure and distant metastasis in squamous cell carcinoma of the head and neck (SCCHN). 
View on Wiley
sbccp.org.br
15 Citations
Background Citations
5

15 Citations

Citation Type

Citation Type

Safety and efficacy of hypofractionated stereotactic body reirradiation in head and neck cancer: Long‐term follow‐up of a large series
TLDR
Long‐term outcomes for a large cohort of patients with head and neck squamous cell carcinoma who underwent stereotactic body radiotherapy (SBRT) reirradiation are reported.
Role of induction chemotherapy for N3 head and neck squamous cell carcinoma.
A New Approach to Survival Analysis of Head and Neck Squamous Cell Carcinoma.
TLDR
Men diagnosed with HNSCC, those with higher grade or advanced state tumor, and those treated by surgery alone are at higher risk of unfavorable outcomes than others and may need more frequent follow-up visits.
Risk factors for distant metastasis in squamous cell carcinoma of the oral cavity.
Predictive factors for long-term survival in head and neck squamous cell carcinoma patients with distant metastasis after initial definitive treatment
TLDR
In the absence of risk factors, long-term survival can be achieved despite the development of DM after definitive treatment, and patients who did not have any of these risk factors had the most favorable outcomes.
Factors predicting the development of distant metastases in patients with head and neck squamous cell carcinoma: A retrospective study from a single centre.
TLDR
Patients with the presence of distant metastases after the initial treatment of head and neck squamous cell carcinoma is associated with a poor outcome and should be considered candidates for adjuvant systemic treatment and evaluated for early detection of DMs during follow-up.
Overall survival of Filipino patients with squamous cell carcinoma of the head and neck: a single-institution experience.
TLDR
The incidence and overall survival of patients with squamous cell carcinoma of the head and neck from the extreme northern part of the Philippines is presented and prognostic factors associated with survival are analysed.
Squamous cell carcinoma of the oral cavity and circulating tumour cells.
TLDR
The detection of CTCs/DTCs is a promising tool to determine the individual need for therapeutic intervention and could supplement routine staging in OSCC, an exceedingly heterogeneous subgroup of head and neck cancer.
Recent Research on Combination of Radiotherapy with Targeted Therapy or Immunotherapy in Head and Neck Squamous Cell Carcinoma: A Review for Radiation Oncologists
TLDR
The latest evidence that supports concurrent radiotherapy with cisplatin which remains the SOC for locally advanced HNSCC (LA-HNSCC), and the potential of combining immunotherapy with radiotherapy as a treatment de-escalating strategy in HPV-associated oropharyngeal carcinoma are discussed.
Phase I/II trial of Durvalumab plus Tremelimumab and stereotactic body radiotherapy for metastatic head and neck carcinoma
TLDR
This is the first clinical trial combining effects of SBRT with dual checkpoint blockade with durvalumab and tremelimumab in the treatment of metastatic HNSCC and it is hypothesize that dual targeting of PD-L1 and CTLA-4 pathways combined with S BRT will lead to < 35% grade 3–5 acute toxicities related to TTC.
...
1
2
...

References

SHOWING 1-10 OF 24 REFERENCES
Impact of average weekly dose of radiation during radiotherapy alone or chemoradiotherapy in head and neck cancer
TLDR
This work investigated patient outcomes using a new parameter: the average weekly dose (AWD), which has been shown to improve locoregional control (LRC) and overall survival (OS) in squamous cell cancer of the head and neck.
Distant metastases in epidermoid cell carcinoma of the head and neck
The pattern of metastases in patients who died of epidermoid cancer of the head and neck area, between 1954 and 1967, at the Veterans Administration Research Hospital, Chicago, was studied. One…
Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer.
TLDR
Induction chemotherapy with the addition of docetaxel significantly improved progression-free and overall survival in patients with unresectable squamous-cell carcinoma of the head and neck.
Prognostic factors for loco/regional control and metastasis and the impact on survival.
Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer.
TLDR
Patients with squamous-cell carcinoma of the head and neck who received docetaxel plus cisplatin and fluorouracil induction chemotherapy plus chemoradiotherapy had a significantly longer survival than did patients who received cisPlatin and fluoride induction chemotherapyplus cheMoradiotherapy.
The effect of local-regional control on distant metastatic dissemination in carcinoma of the head and neck: results of an analysis from the RTOG head and neck database.
The effect of local control on metastatic dissemination in carcinoma of the prostate: long-term results in patients treated with 125I implantation.
Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients.
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck.
TLDR
Treatment of locoregionally advanced head and neck cancer with concomitant high-dose radiotherapy plus cetuximab improves locoreGional control and reduces mortality without increasing the common toxic effects associated with radiotherapy to the head andneck.
Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis
...
1
2
3
...