Locomotor circuits in the mammalian spinal cord.

@article{Kiehn2006LocomotorCI,
  title={Locomotor circuits in the mammalian spinal cord.},
  author={Ole Kiehn},
  journal={Annual review of neuroscience},
  year={2006},
  volume={29},
  pages={
          279-306
        }
}
  • O. Kiehn
  • Published 15 June 2006
  • Biology
  • Annual review of neuroscience
Intrinsic spinal networks, known as central pattern generators (CPGs), control the timing and pattern of the muscle activity underlying locomotion in mammals. This review discusses new advances in understanding the mammalian CPGs with a focus on experiments that address the overall network structure as well as the identification of CPG neurons. I address the identification of excitatory CPG neurons and their role in rhythm generation, the organization of flexor-extensor networks, and the… 

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Recent advances on inhibitory synaptic transmission in mammalian spinal CPGs, mainly from studies in the developing rodent spinal cord utilizing electrophysiology, molecular and genetic approaches are discussed.

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Key features considered to be expressed by locomotor rhythm-generating neurons are summarized and the different genetically defined classes of interneurons which have been proposed to be involved are described.

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...

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