Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: Involvement of adenosine and dopamine receptors
@article{Feduccia2012LocomotorAB, title={Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: Involvement of adenosine and dopamine receptors}, author={Allison A. Feduccia and Yuanyuan Wang and Jeffrey A. Simms and Henry Yi and Rui Li and Leonard F. Bjeldanes and Chuang-xing Ye and Selena E Bartlett}, journal={Pharmacology Biochemistry and Behavior}, year={2012}, volume={102}, pages={241-248} }
36 Citations
Assessment of the Drug-Drug Interaction Potential Between Theacrine and Caffeine in Humans.
- Medicine, BiologyJournal of caffeine research
- 2017
Hemodynamic parameters were unaltered despite the pharmacokinetic interaction, suggesting that coadministration of caffeine and theacrine is safe at the doses administered, and Enhanced oral bioavailability is the most likely mechanism by which caffeine alters the ACrine exposure.
Theacrine, a purine alkaloid from kucha, protects against Parkinson's disease through SIRT3 activation.
- BiologyPhytomedicine : international journal of phytotherapy and phytopharmacology
- 2020
A Two-Part Approach to Examine the Effects of Theacrine (TeaCrine®) Supplementation on Oxygen Consumption, Hemodynamic Responses, and Subjective Measures of Cognitive and Psychometric Parameters
- MedicineJournal of dietary supplements
- 2017
The impact of theacrine (TeaCrine®, TC) was used to examine subjective dose–response, daily changes in cognitive and psychometric parameters, and changes in gas exchange and vital signs in humans to better ascertain the previously reported animal and human outcomes involvingTheacrine administration.
A Toxicological Evaluation of Methylliberine (Dynamine®)
- BiologyJournal of toxicology
- 2019
The toxicological investigation of a pure, synthetic form of methylliberine, a methoxiuric acid present at low levels in various Coffea plants, found no toxicological data in the public domain, and no mortality or morbidity was observed and no toxicologically relevant clinical effects or effects on clinical pathology parameters were observed.
Caffeine and Methylliberine: A Human Pharmacokinetic Interaction Study
- Medicine, BiologyJournal of Exercise and Nutrition
- 2022
It is found that methylliberine altered caffeine pharmacokinetics without a reciprocal interaction, which suggests caffeine may interact uniquely with different methylurates.
Assessment of Pharmacokinetic Interaction Potential Between Caffeine and Methylliberine
- Medicine, BiologymedRxiv
- 2021
It is found that methylliberine altered caffeine pharmacokinetics without a reciprocal interaction, which suggests caffeine may interact uniquely with different methylurates.
Theacrine, a purine alkaloid obtained from Camellia assamica var. kucha, attenuates restraint stress-provoked liver damage in mice.
- BiologyJournal of agricultural and food chemistry
- 2013
Oral administration of theacrine was found to decrease plasma ALT and AST levels, reduce hepatic mRNA levels of inflammatory mediators, and reverse the histologic damages in stressed mice, suggesting that the ACrine is possibly a good candidate for protecting against or treating lifestyle diseases and might contribute to the study of natural products.
Cognitive Performance and Mood Following Ingestion of a Theacrine-Containing Dietary Supplement, Caffeine, or Placebo by Young Men and Women
- PsychologyNutrients
- 2015
TheaTrim treatment does not result in a statistically significant improvement in cognitive performance but may favorably impact multiple subjective feelings related to energy and mood, as well as objective measures of cognitive performance, heart rate, and blood pressure.
Attenuation of Tumor Development in Mammary Carcinoma Rats by Theacrine, an Antagonist of Adenosine 2A Receptor
- Biology, MedicineMolecules
- 2021
Theacrine was demonstrated to be an effective antagonist of the adenosine 2A receptor as its concurrent supplementation significantly reduced the elevation of AMPK phosphorylation level in MCF-7 human breast cells induced by CGS21680, an agonist of adenosines 2A receptors.
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