Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: Involvement of adenosine and dopamine receptors

@article{Feduccia2012LocomotorAB,
  title={Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: Involvement of adenosine and dopamine receptors},
  author={Allison A. Feduccia and Yuanyuan Wang and Jeffrey A. Simms and Henry Yi and Rui Li and Leonard F. Bjeldanes and Chuang-xing Ye and Selena E Bartlett},
  journal={Pharmacology Biochemistry and Behavior},
  year={2012},
  volume={102},
  pages={241-248}
}

Assessment of the Drug-Drug Interaction Potential Between Theacrine and Caffeine in Humans.

Hemodynamic parameters were unaltered despite the pharmacokinetic interaction, suggesting that coadministration of caffeine and theacrine is safe at the doses administered, and Enhanced oral bioavailability is the most likely mechanism by which caffeine alters the ACrine exposure.

Theacrine, a purine alkaloid from kucha, protects against Parkinson's disease through SIRT3 activation.

A Two-Part Approach to Examine the Effects of Theacrine (TeaCrine®) Supplementation on Oxygen Consumption, Hemodynamic Responses, and Subjective Measures of Cognitive and Psychometric Parameters

The impact of theacrine (TeaCrine®, TC) was used to examine subjective dose–response, daily changes in cognitive and psychometric parameters, and changes in gas exchange and vital signs in humans to better ascertain the previously reported animal and human outcomes involvingTheacrine administration.

A Toxicological Evaluation of Methylliberine (Dynamine®)

The toxicological investigation of a pure, synthetic form of methylliberine, a methoxiuric acid present at low levels in various Coffea plants, found no toxicological data in the public domain, and no mortality or morbidity was observed and no toxicologically relevant clinical effects or effects on clinical pathology parameters were observed.

Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use

These findings support the clinical safety and non-habituating neuro-energetic effects of TeaCrine® supplementation over 8 weeks of daily use (up to 300 mg/day) and there was no evidence of a tachyphylactic response that is typical of neuroactive agents such as caffeine and other stimulants.

Caffeine and Methylliberine: A Human Pharmacokinetic Interaction Study

It is found that methylliberine altered caffeine pharmacokinetics without a reciprocal interaction, which suggests caffeine may interact uniquely with different methylurates.

Assessment of Pharmacokinetic Interaction Potential Between Caffeine and Methylliberine

It is found that methylliberine altered caffeine pharmacokinetics without a reciprocal interaction, which suggests caffeine may interact uniquely with different methylurates.

Theacrine, a purine alkaloid obtained from Camellia assamica var. kucha, attenuates restraint stress-provoked liver damage in mice.

Oral administration of theacrine was found to decrease plasma ALT and AST levels, reduce hepatic mRNA levels of inflammatory mediators, and reverse the histologic damages in stressed mice, suggesting that the ACrine is possibly a good candidate for protecting against or treating lifestyle diseases and might contribute to the study of natural products.

Cognitive Performance and Mood Following Ingestion of a Theacrine-Containing Dietary Supplement, Caffeine, or Placebo by Young Men and Women

TheaTrim treatment does not result in a statistically significant improvement in cognitive performance but may favorably impact multiple subjective feelings related to energy and mood, as well as objective measures of cognitive performance, heart rate, and blood pressure.

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