Locomotion defects, together with Pins, regulates heterotrimeric G-protein signaling during Drosophila neuroblast asymmetric divisions.

@article{Yu2005LocomotionDT,
  title={Locomotion defects, together with Pins, regulates heterotrimeric G-protein signaling during Drosophila neuroblast asymmetric divisions.},
  author={Fengwei Yu and Hongyan Wang and Hongliang Qian and Rachna Kaushik and Mary Bownes and Xiaohang Yang and William N. Chia},
  journal={Genes & development},
  year={2005},
  volume={19 11},
  pages={1341-53}
}
Heterotrimeric G proteins mediate asymmetric division of Drosophila neuroblasts. Free Gbetagamma appears to be crucial for the generation of an asymmetric mitotic spindle and consequently daughter cells of distinct size. However, how Gbetagamma is released from the inactive heterotrimer remains unclear. Here we show that Locomotion defects (Loco) interacts and colocalizes with Galphai and, through its GoLoco motif, acts as a guanine nucleotide dissociation inhibitor (GDI) for Galphai… CONTINUE READING