Locked nucleic acids (LNA): versatile tools for designing oligonucleotide decoys with high stability and affinity.

@article{Crinelli2004LockedNA,
  title={Locked nucleic acids (LNA): versatile tools for designing oligonucleotide decoys with high stability and affinity.},
  author={Rita Crinelli and Marzia Bianchi and L. Gentilini and Linda Palma and Mauro Magnani},
  journal={Current drug targets},
  year={2004},
  volume={5 8},
  pages={
          745-52
        }
}
Double-stranded oligodeoxynucleotides (ODN) containing the consensus binding sequence of a transcription factor are valuable tools for the manipulation of gene expression at the transcriptional level by means of the decoy strategy. The approach involves flooding the cells with enough ODN decoy to compete for binding of the transcription factor with its consensus sequence in target genes. The technique has been proven effective in vitro and in vivo, suggesting its use in therapy. Therefore… CONTINUE READING

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