Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia

  title={Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia},
  author={Elli Papaemmanuil and Fay Julie Hosking and Jayaram Vijayakrishnan and Amy E Price and Bianca D. Olver and Eammon Sheridan and S. E. Kinsey and Tracy J Lightfoot and Eve Roman and J. E. Irving and James M. Allan and Ian P. M. Tomlinson and Malcolm A M R Taylor and Mel F. Greaves and Richard S. Houlston},
  booktitle={Nature Genetics},
To identify risk variants for childhood acute lymphoblastic leukemia (ALL), we conducted a genome-wide association study of two case-control series, analyzing the genotypes with respect to 291,423 tagging SNPs in a total of 907 ALL cases and 2,398 controls. We identified risk loci for ALL at 7p12.2 (IKZF1, rs4132601, odds ratio (OR) = 1.69, P = 1.20 × 10−19), 10q21.2 (ARID5B, rs7089424, OR = 1.65, P = 6.69 × 10−19) and 14q11.2 (CEBPE, rs2239633, OR = 1.34, P = 2.88 × 10−7). The 10q21.2 (ARID5B… CONTINUE READING
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