Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease

  title={Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease},
  author={Subra Kugathasan and Robert N Baldassano and Jonathan P. Bradfield and Patrick Sleiman and Marcin Imielinski and Stephen L Guthery and Salvatore Cucchiara and Cecilia Kim and Edward C. Frackelton and Kiran Annaiah and Joseph T. Glessner and Erin Santa and Tara Willson and Andrew W. Eckert and Erin L Bonkowski and Julie L. Shaner and Ryan M. Smith and Frederick G Otieno and Nicholas D. Peterson and Debra J. Abrams and Rosetta Chiavacci and Robert Grundmeier and Peter Mamula and Gitit Tomer and David A. Piccoli and Dimitri S. Monos and Vito Annese and Lee A. Denson and Struan F. A. Grant and Hakon Hakonarson},
  journal={Nature Genetics},
Inflammatory bowel disease (IBD) is a common inflammatory disorder with complex etiology that involves both genetic and environmental triggers, including but not limited to defects in bacterial clearance, defective mucosal barrier and persistent dysregulation of the immune response to commensal intestinal bacteria. IBD is characterized by two distinct phenotypes: Crohn's disease (CD) and ulcerative colitis (UC). Previously reported GWA studies have identified genetic variation accounting for a… CONTINUE READING
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