Loci of intestinal distress in cystic fibrosis knockout mice.

@article{Haston2003LociOI,
  title={Loci of intestinal distress in cystic fibrosis knockout mice.},
  author={Christina K. Haston and Lap-chee Tsui},
  journal={Physiological genomics},
  year={2003},
  volume={12 2},
  pages={79-84}
}
The strain-dependent survival of cystic fibrosis (CF) knockout mice has been used to map a modifier of CF, Cfm1, in mice and, subsequently, in humans. To identify additional modifiers of the CF phenotype, in this study, the survival of F2 CF mice derived from a cross between congenic C57BL/6J CF and BALB/cJ CF heterozygotes was followed up to 12 wk of age. A genome-wide linkage scan completed in F2 CF mice revealed a chromosome 10 locus (P = 1.2 x 10(-4)) to predict for intestinal distress in… CONTINUE READING