Location on heparin of the oligosaccharide section essential for anticoagulant activity.


Studies were conducted to define the location of the unique oligosaccharide sequence in heparin that is required for its anticoagulant activity. A heparin fraction with an average molecular weight of 20,000 was linked at its reducing terminus to a Sepharose derivative via an azo bridge. The matrix-linked heparin was subjected to limited degradation with… (More)


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