Corpus ID: 9977315

Location of penetration and metabolic barriers to levobunolol in the corneal epithelium of the pigmented rabbit.

@article{Ashton1991LocationOP,
  title={Location of penetration and metabolic barriers to levobunolol in the corneal epithelium of the pigmented rabbit.},
  author={P. Ashton and W. Wang and V. Lee},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1991},
  volume={259 2},
  pages={
          719-24
        }
}
  • P. Ashton, W. Wang, V. Lee
  • Published 1991
  • Biology, Medicine
  • The Journal of pharmacology and experimental therapeutics
The objective of this study was to determine which of the five or six corneal epithelial layers was rate-limiting in the corneal penetration and metabolism of levobunolol in the pigmented rabbit. Corneal penetration and metabolism were evaluated using the isolated cornea in the modified Ussing chamber. Levobunolol and its metabolite, dihydrolevobunolol, were assayed by reversed phase high-performance liquid chromatography using spectrophotometric detection. EDTA (0.1 and 0.5%) and benzalkonium… Expand
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