Location of amino acid residues important for the structure and biological function of the haemagglutinin-neuraminidase glycoprotein of Sendai virus by analysis of escape mutants.

@article{Lyn1991LocationOA,
  title={Location of amino acid residues important for the structure and biological function of the haemagglutinin-neuraminidase glycoprotein of Sendai virus by analysis of escape mutants.},
  author={Dominic A. Lyn and Mary B. Mazanec and John G. Nedrud and Allen Portner},
  journal={The Journal of general virology},
  year={1991},
  volume={72 ( Pt 4)},
  pages={817-24}
}
To locate sites important for the structure and function of the haemagglutinin-neuraminidase glycoprotein (HN) of Sendai virus, the biological characteristics of antibody-selected escape mutants were correlated with mutations in the primary HN amino acid sequence. An escape mutant virus deficient only in neuraminidase function but with an HN content equal to that of the wild-type virus had an amino acid change at residue 184, implying that this position may be important for maintaining a… CONTINUE READING

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