Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates.

@article{Strop2013LocationMS,
  title={Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates.},
  author={Pavel Strop and S Liu and Magdalena Dorywalska and Kathy Delaria and Russell G Dushin and Thomas-Toan Tran and W B Ho and Santiago Esteban Farias and Meritxell Galindo Casas and Yasmina Noubia Abdiche and Dahui Zhou and Ramalakshmi Y Chandrasekaran and Caroline Samain and Carole Loo and Andrea Rossi and Mathias Rickert and Stellanie Krimm and Teresa W T Wong and Sherman Michael Chin and Jessica J. Yu and Jeanette Dilley and Javier Chaparro-Riggers and Gary F Filzen and Christopher J. O'Donnell and Fang Wang and Jeremy S. Myers and Jaume Pons and David L. Shelton and Arvind Rajpal},
  journal={Chemistry & biology},
  year={2013},
  volume={20 2},
  pages={161-7}
}
Antibody drug conjugates (ADCs) are a therapeutic class offering promise for cancer therapy. The attachment of cytotoxic drugs to antibodies can result in an effective therapy with better safety potential than nontargeted cytotoxics. To understand the role of conjugation site, we developed an enzymatic method for site-specific antibody drug conjugation using microbial transglutaminase. This allowed us to attach diverse compounds at multiple positions and investigate how the site influences… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 101 extracted citations

Innovations for Next-Generation Antibody-Drug Conjugates

Cancer Drug Discovery and Development • 2018
View 20 Excerpts
Highly Influenced

Antibody–drug conjugates for targeted anticancer drug delivery

Journal of Pharmaceutical Investigation • 2016
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…