Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA.

@article{Luciw1983LocationAF,
  title={Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA.},
  author={Paul A. Luciw and J. Michael Bishop and H. E. Varmus and Mario R Capecchi},
  journal={Cell},
  year={1983},
  volume={33 3},
  pages={705-16}
}
Biochemical transformation of thymidine-kinase-deficient (TK-) mouse L cells is enhanced 20 to 40 fold when microinjected plasmid DNA contains regions of the genomes of Rous sarcoma virus or simian virus 40 in addition to the complete herpes simplex virus tk gene, irrespective of the orientation and location of the enhancer. The enhancing sequence of RSV DNA has been localized to 143 bp that include 88 bp at the 5' end of the long terminal repeat; the enhancing segment of SV40 DNA lies 42-276… CONTINUE READING
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