Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling

@article{Tobin2008LocationLL,
  title={Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling},
  author={Andrew B. Tobin and Adrian J. Butcher and Kok Choi Kong},
  journal={Trends in Pharmacological Sciences},
  year={2008},
  volume={29},
  pages={413 - 420}
}
  • Andrew B. Tobin, Adrian J. Butcher, Kok Choi Kong
  • Published 2008
  • Biology, Medicine
  • Trends in Pharmacological Sciences
  • It is now established that most of the ∼800 G-protein-coupled receptors (GPCRs) are regulated by phosphorylation in a process that results in the recruitment of arrestins, leading to receptor desensitization and the activation of arrestin-dependent processes. This generalized view of GPCR regulation, however, does not provide an adequate mechanism for the control of tissue-specific GPCR signalling. Here, we review the evidence that GPCR phosphorylation is, in fact, a flexible and dynamic… CONTINUE READING

    Figures, Tables, and Topics from this paper.

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 176 CITATIONS, ESTIMATED 41% COVERAGE

    Phosphorylation of G Protein-Coupled Receptors: From the Barcode Hypothesis to the Flute Model

    VIEW 1 EXCERPT
    CITES BACKGROUND

    β-arrestin signalling and bias in hormone-responsive GPCRs

    VIEW 1 EXCERPT
    CITES BACKGROUND

    Dissecting the signaling features of the multi-protein complex GPCR/β-arrestin/ERK1/2.

    VIEW 5 EXCERPTS
    CITES BACKGROUND & RESULTS
    HIGHLY INFLUENCED

    Molecular Mechanisms of GPCR Signaling: A Structural Perspective

    VIEW 2 EXCERPTS
    CITES BACKGROUND & RESULTS

    Signal transduction by protease-activated receptors.

    VIEW 1 EXCERPT
    CITES BACKGROUND

    Structural Basis of Arrestin-Dependent Signal Transduction.

    VIEW 1 EXCERPT
    CITES BACKGROUND

    FILTER CITATIONS BY YEAR

    2008
    2020

    CITATION STATISTICS

    • 9 Highly Influenced Citations

    • Averaged 14 Citations per year from 2018 through 2020

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 76 REFERENCES