Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling

Abstract

It is now established that most of the approximately 800 G-protein-coupled receptors (GPCRs) are regulated by phosphorylation in a process that results in the recruitment of arrestins, leading to receptor desensitization and the activation of arrestin-dependent processes. This generalized view of GPCR regulation, however, does not provide an adequate… (More)
DOI: 10.1016/j.tips.2008.05.006

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