Locally targeted cytoprotection with dextran sulfate attenuates experimental porcine myocardial ischaemia/reperfusion injury.

@article{Banz2005LocallyTC,
  title={Locally targeted cytoprotection with dextran sulfate attenuates experimental porcine myocardial ischaemia/reperfusion injury.},
  author={Yara Banz and Otto Martin Hess and Simon C. Robson and Daniel Mettler and Pascal Meier and Andr{\'e} Haeberli and Eva Csizmadia and Elena Y. Korchagina and Nicolai V. Bovin and Robert Rieben},
  journal={European heart journal},
  year={2005},
  volume={26 21},
  pages={
          2334-43
        }
}
AIMS Intravascular inflammatory events during ischaemia/reperfusion injury following coronary angioplasty alter and denudate the endothelium of its natural anticoagulant heparan sulfate proteoglycan (HSPG) layer, contributing to myocardial tissue damage. We propose that locally targeted cytoprotection of ischaemic myocardium with the glycosaminoglycan analogue dextran sulfate (DXS, MW 5000) may protect damaged tissue from reperfusion injury by functional restoration of HSPG. METHODS AND… CONTINUE READING

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