Locally instilled tumor necrosis factor α antisense oligonucleotide contributes to inhibition of TH 2-driven pulmonary fibrosis via induced CD4+ CD25+ Foxp3+ regulatory T cells.

@article{Luo2013LocallyIT,
  title={Locally instilled tumor necrosis factor α antisense oligonucleotide contributes to inhibition of TH 2-driven pulmonary fibrosis via induced CD4+ CD25+ Foxp3+ regulatory T cells.},
  author={Yi Luo and Min Wang and Zhonghua Pang and Fengtao Jiang and Jiangning Chen and Junfeng Zhang},
  journal={The journal of gene medicine},
  year={2013},
  volume={15 11-12},
  pages={441-52}
}
BACKGROUND Anti-tumor necrosis factor α therapeutics has the potential to alleviate pulmonary fibrosis. However, the systemic administration of anti-tumor necrosis factor α agents has brought about contradictory results and frequent adverse effects, such as infections, immunogenicity and malignancies, amongst others. In the present study, we attempted the local administration of tumor necrosis factor α antisense oligonucleotide and evaluated the treatment effects on pulmonary fibrosis in a… CONTINUE READING
4 Citations
38 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 38 references

Tumour necrosis factor-α regulation of Local anti-TNF-α therapy on pulmonary fibrosis

  • AJ Wu, H Hua, SH Munson
  • J Gene Med
  • 2013
1 Excerpt

Global impairment of CD4CD25FOXP3 regulatory Tcells in idiopathic pulmonary fibrosis

  • I Kotsianidis, E Nakou, I Bouchliou
  • Am J Respir Crit Care Med
  • 2009
1 Excerpt

Similar Papers

Loading similar papers…