Locally formed dopamine inhibits Na+-K+-ATPase activity in rat renal cortical tubule cells.

@article{Seri1988LocallyFD,
  title={Locally formed dopamine inhibits Na+-K+-ATPase activity in rat renal cortical tubule cells.},
  author={Istvan Seri and Bruce C. Kone and Steven R. Gullans and Anita C. Aperia and Barry M. Brenner and Barbara J Ballermann},
  journal={The American journal of physiology},
  year={1988},
  volume={255 4 Pt 2},
  pages={F666-73}
}
Dopamine, generated locally from L-dopa, inhibits Na+-K+-ATPase in permeabilized rat proximal tubules under maximum transport rate conditions for sodium. To determine whether locally formed dopamine inhibits Na+-K+-ATPase activity in intact cortical tubule cells we studied the effect of L-dopa on ouabain-sensitive oxygen consumption rate (QO2) and 86Rb uptake in renal cortical tubule cell suspensions. L-Dopa (10(-4) M) did not affect ouabain-insensitive QO2 or mitochondrial respiration. However… CONTINUE READING

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