Locally delivered rhTGF‐β2 enhances bone ingrowth and bone regeneration at local and remote sites of skeletal injury

@article{Sumner2001LocallyDR,
  title={Locally delivered rhTGF‐$\beta$2 enhances bone ingrowth and bone regeneration at local and remote sites of skeletal injury},
  author={Sumner and T. Turner and R. Urban and R. Leven and M. Hawkins and E. Nichols and J. McPherson and J. Galante},
  journal={Journal of Orthopaedic Research},
  year={2001},
  volume={19}
}
The purposes of the present study were to determine if recombinant human transforming growth factor‐beta‐2 (rhTGF‐β2) enhances bone ingrowth into porous‐coated implants and bone regeneration in gaps between the implant and surrounding host bone. The implants were placed bilaterally for four weeks in the proximal humeri of skeletally mature, adult male dogs in the presence of a 3‐mm gap. In three treatment groups of animals, the test implant was treated with hydroxyapatite/tricalcium phosphate… Expand
Locally delivered rhBMP‐2 enhances bone ingrowth and gap healing in a canine model
TLDR
Application of rhBMP‐2 to a porous‐coated implant stimulated local bone ingrowth and gap healing and the enhancement of bone formation within the implant (bone ingrowth) was inversely related to dose. Expand
Aging Does Not Lessen the Effectiveness of TGFβ2‐Enhanced Bone Regeneration
  • D. R. Sumner, T. Turner, +4 authors J. McPherson
  • Biology, Medicine
  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2003
TLDR
Age did not significantly affect the quantity of new bone formed as assessed by backscatter scanning electron microscopy, but the older animals had thinner regenerated trabeculae that tended to be spaced more closely than the younger animals, which suggest that there may have been a slight delay in the rate or a defect of mineralization in the old animals. Expand
Depressed Bone Mineralization Following High Dose TGF-β1 Application in an Orthopedic Implant Model
TLDR
Quantitative backscatter scanning electron microscopy is used to test the effect of TGF-β1 on mineralization of regenerated bone by examining tissue samples from a previously published canine study in which it was found increased bone formation. Expand
Local application of rhTGF-beta2 enhances peri-implant bone volume and bone-implant contact in a rat model.
TLDR
Peri-implant bone volume as a response to TGF-beta treatment in a rodent model and variance in implant fixation strength was examined to provide a platform for studying molecular mechanisms of growth factor stimulated bone regeneration and implant fixation. Expand
Additive enhancement of implant fixation following combined treatment with rhTGF-beta2 and rhBMP-2 in a canine model.
TLDR
In this animal model, the combined use of TGF-beta2 and BMP-2 led to more secure mechanical fixation of the implant than did the use of either growth factor alone and demonstrated results that were similar to those associated with theUse of autogenous bone graft. Expand
Osseointegration by bone morphogenetic protein-2 and transforming growth factor beta2 coated titanium implants in femora of New Zealand white rabbits
TLDR
The results of this study confirm the results of other studies that a coating with growth factors is able to enhance bone implant ingrowth and may be of importance in defect situations during revision surgery to support the implant ing growth and implant anchorage. Expand
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TLDR
The results in a canine implant model demonstrated that a narrow range of BMP‐2 doses have opposite effects in bridging an empty peri‐implant gap with bone, when combined with systemic zoledronate. Expand
Effect of recombinant human transforming growth factor-beta2 dose on bone formation in rat femur titanium implant model.
TLDR
While rhTGF-beta2 was able to enhance bone formation in the vicinity of the implant, the relative lack of bone-implant contact in the 20 microg group depressed the strength of fixation, suggesting that the location as well as the amount of new bone formed is important for implant fixation. Expand
Porous implants as drug delivery vehicles to augment host tissue integration
TLDR
It is suggested that solid prostheses can be transformed into porous implants to serve as drug delivery carriers, from which control‐released bioactive cues augment host tissue integration. Expand
Collagen-hydroxyapatite/tricalcium phosphate microspheres as a delivery system for recombinant human transforming growth factor-beta 1.
TLDR
Collagen-hydroxyapatite/tricalcium phosphate microspheres were a good carrier for rhTGF-beta 1 and it was apparent that bone regeneration was influenced by the addition of rhT GF- beta 1. Expand
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References

SHOWING 1-10 OF 42 REFERENCES
Transforming growth factor‐β1 enhances bone healing to unloaded tricalcium phosphate coated implants: An experimental study in dogs
TLDR
It is suggested that recombinant human transforming growth factor‐β1 adsorbed onto implants coated with tricalcium phosphate ceramic can enhance mechanical fixation and bone growth on the implant. Expand
TRANSFORMING GROWTH FACTOR-β1 STIMULATES BONE ONGROWTH TO WEIGHT-LOADED TRICALCIUM PHOSPHATE COATED IMPLANTS: AN EXPERIMENTAL STUDY IN DOGS
TLDR
This study suggests that rhTGF-β1 adsorbed on TCP-ceramic-coated implants can enhance bone ongrowth and mechanical fixation. Expand
Enhancement of bone ingrowth by transforming growth factor-beta.
TLDR
The data from the present investigation indicate that enhancement of bone ingrowth in implants that have been treated with a combination of a hydroxyapatite-tricalcium phosphate coating and transforming growth factor-beta 1 may exceed that obtainable with grafting of the gap with autogenous cancellous bone. Expand
Transforming growth factor-beta stimulates bone ongrowth. Hydroxyapatite-coated implants studied in dogs.
TLDR
Unloaded cylindrical grit-blasted titanium implants coated with hydroxyapatite ceramic were inserted into the proximal part of the humerus of 20 skeletally mature Labrador dogs and RhTGF-beta 1 only moderately enhanced bone ongrowth to hydroxyAPatite-coated implants. Expand
Stimulation of bone healing by transforming growth factor-beta 1 released from polymeric or ceramic implants.
TLDR
Preliminary studies show that TGF-beta 1 is capable of inducing new bone formation and the materials used to deliver the growth factor can play a significant role in the bone healing process. Expand
TGF‐β1 induces bone closure of skull defects: Temporal dynamics of bone formation in defects exposed to rhTGF‐β1
TLDR
Results indicate that exogenously applied rhTGF‐β1 stimulated the recruitment and proliferation of osteoblasts at the defect site, resulting in a rapid deposition of bony matrix, with normal remodeling processes occurring thereafter. Expand
Transforming growth factor-beta accelerates osteoinduction in a craniofacial onlay model.
Recombinant human transforming growth factor beta 1 was added to a demineralized bone matrix (DBM) paste, formed into cylinders and implanted onto the cranial periosteum of New Zealand White rabbits.Expand
Controlled release of TGF-β1 from a biodegradable matrix for bone regeneration
Although bone has a remarkable capacity for regenerative growth, there are many clinical situations in which the bony repair process is impaired. TGF-beta 1 is a 25 kD homodimeric protein whichExpand
Efficacy of autograft and freeze‐dried allograft to enhance fixation of porous coated implants in the presence of interface gaps
TLDR
Treatment with autograft significantly increased the amount of bone ingrowth within the implants by nearly three‐fold at 4 weeks and eight-fold at 8 weeks, and the enhancing effect was recognizable as early as 2 weeks. Expand
Recombinant TGF‐β1 stimulates bone marrow osteoprogenitor cell activity and bone matrix synthesis in osteopenic, old male mice
TLDR
The findings demonstrate that the osteopenic changes seen in the skeletons of old male BALB/c mice are due to reductions in the availability and/or synthesis of bone TGF‐β which results in fewer, less osteogenic marrow osteoprogenitor cells (CFU‐f) and lower levels of bone formation. Expand
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