Localizing multiple X chromosome-linked retinitis pigmentosa loci using multilocus homogeneity tests.

@article{Ott1990LocalizingMX,
  title={Localizing multiple X chromosome-linked retinitis pigmentosa loci using multilocus homogeneity tests.},
  author={J{\"u}rg Ott and Sabyasachi Bhattacharya and Jen Chen and Michael J. Denton and Jennifer Donald and Christopher Dubay and G. Jane Farrar and Gerald Allen Fishman and DISTANCESS. Frey and A. Gal},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 2},
  pages={701-4}
}
Multilocus linkage analysis of 62 family pedigrees with X chromosome-linked retinitis pigmentosa (XLRP) was undertaken to determine the presence of possible multiple disease loci and to reliably estimate their map location. Multilocus homogeneity tests furnished convincing evidence for the presence of two XLRP loci, the likelihood ratio being 6.4 x 10(9):1 in favor of two versus a single XLRP locus and gave accurate estimates for their map location. In 60-75% of the families, location of an… CONTINUE READING

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