Localizing matrix metalloproteinase activities in the pericellular environment.

  title={Localizing matrix metalloproteinase activities in the pericellular environment.},
  author={Gillian Murphy and Hideaki Nagase},
  journal={The FEBS journal},
  volume={278 1},
Matrix metalloproteinases (MMPs) are a group of structurally related proteolytic enzymes containing a zinc ion in the active site. They are secreted from cells or bound to the plasma membrane and hydrolyze extracellular matrix (ECM) and cell surface-bound molecules. They therefore play key roles in morphogenesis, wound healing, tissue repair and remodeling in diseases such as cancer and arthritis. Although the cell anchored membrane-type MMPs (MT-MMPs) function pericellularly, the secreted MMPs… CONTINUE READING


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