Localized versus systemic angiotensin II receptor inhibition of intimal hyperplasia in experimental vein grafts by the specific angiotensin II receptor inhibitor L158,809.

@article{Fulton1998LocalizedVS,
  title={Localized versus systemic angiotensin II receptor inhibition of intimal hyperplasia in experimental vein grafts by the specific angiotensin II receptor inhibitor L158,809.},
  author={Gregory J. Fulton and Mark G Davies and Luke Barber and Einar Svendsen and P O Hagen},
  journal={Surgery},
  year={1998},
  volume={123 2},
  pages={
          218-27
        }
}
BACKGROUND This study examines the effect of the angiotensin II receptor (type 1) antagonist (L158,809) on the formation of vein graft intimal hyperplasia in vivo, by both localized and systemic administration. METHODS Forty New Zealand White rabbits underwent carotid interposition bypass grafting with the external jugular vein and were killed on postoperative day 28. To determine the effect of L158,809 on the development of intimal hyperplasia, 10 animals received long-term oral therapy with… CONTINUE READING

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