Localized scleroderma is an autoimmune disorder.

  title={Localized scleroderma is an autoimmune disorder.},
  author={Kazuhiko Takehara and Shigeto Sato},
  volume={44 3},
OBJECTIVES There have been many studies suggesting that localized scleroderma has a strong autoimmune background, although the lesions are usually limited to the skin and subcutaneous tissue. Here we summarize previous data on the autoimmunity of localized scleroderma, mostly published in the last two decades, because there has not been a review paper summarizing autoimmunity in this disorder. METHODS We classified the previous reports into three categories: antinuclear antibodies; cytokine… CONTINUE READING


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