Localized reconstruction of subunits from electron cryomicroscopy images of macromolecular complexes

Abstract

Electron cryomicroscopy can yield near-atomic resolution structures of highly ordered macromolecular complexes. Often however some subunits bind in a flexible manner, have different symmetry from the rest of the complex, or are present in sub-stoichiometric amounts, limiting the attainable resolution. Here we report a general method for the localized three… (More)
DOI: 10.1038/ncomms9843

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