Localized elasticity measured in epithelial cells migrating at a wound edge using atomic force microscopy.

@article{Wagh2008LocalizedEM,
  title={Localized elasticity measured in epithelial cells migrating at a wound edge using atomic force microscopy.},
  author={Ajay A Wagh and Esra Roan and Kenneth E. Chapman and Leena P. Desai and David A. Rendon and Eugene C. Eckstein and Christopher M. Waters},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2008},
  volume={295 1},
  pages={
          L54-60
        }
}
Restoration of lung homeostasis following injury requires efficient wound healing by the epithelium. The mechanisms of lung epithelial wound healing include cell spreading and migration into the wounded area and later cell proliferation. We hypothesized that mechanical properties of cells vary near the wound edge, and this may provide cues to direct cell migration. To investigate this hypothesis, we measured variations in the stiffness of migrating human bronchial epithelial cells (16HBE cells… CONTINUE READING

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