Localized and Transient Transcription of Hox Genes Suggests a Link between Patterning and the Segmentation Clock

@article{Zkny2001LocalizedAT,
  title={Localized and Transient Transcription of Hox Genes Suggests a Link between Patterning and the Segmentation Clock},
  author={J{\'o}zsef Z{\'a}k{\'a}ny and Marie Kmita and Pilar Alarc{\'o}n and Jos{\'e}-Luis de la Pompa and Denis Duboule},
  journal={Cell},
  year={2001},
  volume={106},
  pages={207-217}
}
During development, Hox gene transcription is activated in presomitic mesoderm with a time sequence that follows the order of the genes along the chromosome. Here, we show that Hoxd1 and other Hox genes display dynamic stripes of expression within presomitic mesoderm. The underlying transcriptional bursts may reflect the mechanism that coordinates Hox gene activation with somitogenesis. This mechanism appears to depend upon Notch signaling, as mice deficient for RBPJk, the effector of the Notch… CONTINUE READING
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